Have been able to get photos and swf files to work just fine. But I cannot get an .mov file to work or an .flv file. When I use a .mov file it brings up the lightbox and then locks up whatever browser you use. If I use an .flv file it complains that the file doesn't exist. URL http://www.ackerman-family.org, second post 'Bryan the Boarder' jumps 5 feet. The video is linked to the 'film' icon in the lower right of the post. I followed the instructions at the 'Technical Information' site to no avail. I even tried turning on 'Live HTTP Headers' in firefox to see what was being returned, but the only thing I get is the request for the .MOV file then the browser locks up.
I have only been using prettyphoto for about a week but I may be able to help.
If you look in the javascript .js file you should find the line "function _getFileType(itemSrc)". The reason that flv's don't work is that prettyphoto doesn't have a case for it and assumes it is an image. You need to find a way to modify that function as well as the "open" function. As for the .mov problem I don't really have any idea.